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KMID : 0855520070200040301
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Korean Journal of Physical Anthropology
2007 Volume.20 No. 4 p.301 ~ p.309
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Effect of Whole Body Vibration on Trabecular Bone in OVX Rats
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Ko Chang-Yong
Lee Tae-Woo
Woo Dae-Gon
Kim Hyo-Seon
Lim Do-Hyung
Kim Han-Sung
Lee Beob-Yi
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Abstract
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Previous studies showed that whole body vibration could prevent bone resorption and stimulate new bone formation. The aim of this study is to detect and track effect of whole body vibration for osteoporotic bone of OVX rats.
12 Female rats were used and allocated into 5 group, CON, SHAM, WBV 17, WBV 30 and WBV 45. Rats except SHAM group were ovariectomised to induce osteoporosis. Rats in WBV groups were stimulated whole body vibration at magnitude of 1 ㎜peak-peak and frequency 17 ㎐, 30 ㎐ and 45 ㎐, repectively, for 8 weeks (20 min, 5 days/week). The 4th lumbar in rats were scanned at a resolution of 35 μm at baseline, before stimulation, and 8 weeks by In-vivo Micro-CT. To detect and track changes of morphological characteristics in lumbar trabecuar bone of rats, structural parameters were measured and calculated from acquiring images.
In the results, changes of structural characteristics of WBV group were smaller than those of CON group. Loss of quantity of trabecular bone in WBV 45 was the least. In contrast, that in WBV 17 was the biggest.
These results showed that reasonable whole body vibration beneficially affected osteoporotic bones. In addition to, whole body vibration was likely to be substituted partly for drug treatment.
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KEYWORD
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In-vivo Micro-CT, Osteoporosis, Trabecular bone, Whole body vibration, Morphological characteristics
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